Effectiveness and Safety of COVID-19 Vaccination During Preconceptional and Preclinical Pregnancy Period: A National Population Study
- 주제(키워드) SARS-CoV-2 , COVID-19 , Vaccination , Safety , Pregnancy
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Gwak, Eunseon; Choe, Seung-Ah] Korea Univ, Coll Med, Dept Prevent Med, 73 Goryeodae R, Seoul 02841, South Korea; [Kim, Taemi] Korea Univ, Dept Publ Hlth, Seoul, South Korea; [Shin, Ju-Young] Sungkyunkwan Univ, Sch Pharm, Dept Biohlth Regulatory Sci, Suwon, South Korea; [Choi, Nam-Kyong] Ewha Womans Univ, Coll Sci & Ind Convergence, Dept Hlth Convergence, Seoul, South Korea; [Han, Seungbong] Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; [Lee, Ji Yeon] CHA Univ, CHA Bundang Med Ctr, Sch Med, Dept Obstet & Gynecol, Seongnam, South Korea; [Choe, Young June] Korea Univ, Anam Hosp, Dept Pediat, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Gold Open Access; Green Published
- 발행기관 KOREAN ACAD MEDICAL SCIENCES
- 발행년도 2023
- URI http://www.dcollection.net/handler/ewha/000000213706
- 본문언어 영어
- Published As https://doi.org/10.3346/jkms.2023.38.e314
- PubMed 37873626
초록/요약
Background: We aimed to assess the risk of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and early abortive outcomes after the association between coronavirus disease 2019 (COVID-19) vaccination during the preconceptional period and preclinical pregnancy, which are likely to be inadvertent vaccination. Methods: We used data from the Korea Disease Control and Prevention Agency-COVID19-National Health Insurance Service cohort from December 2020 to December 2021. The vaccinated pregnant women were matched to unvaccinated pregnant controls at a 1:4 ratio. The risks of SARS-CoV-2 infection and intensive care unit (ICU) admission within 14 days of infection were analyzed to assess its effectiveness. For safety measures, the adjusted relative risks (aRRs) of early abortive outcomes for the first COVID-19 vaccination during the preconceptional and preclinical periods were calculated considering covariates. We compared the risk of early abortion between mRNA and viral vector vaccines.Results: The overall COVID-19 vaccination rates during the preconceptional period and preclinical pregnancy were 3.1% (6,662/215,211) and 2.6% (5,702/215,211), respectively. The cumulative incidence of ICU admission within 14 days of SARS-CoV-2 infection was 6/100,000 in the unvaccinated group, whereas there were no ICU admissions in the vaccinated groups. The risks of early abortive outcomes were not significantly different between the preconceptional vaccination group and the unvaccinated group (aRR, 1.04; 95% confidence interval [CI],0.99-1.10) or between preclinical pregnancy vaccination and their matched controls (1.02; 95% CI, 0.96-1.08). mRNA and viral vector vaccines have shown similar risks for early abortive outcomes and miscarriages. Conclusion: Our findings have provided compelling evidence regarding the effectiveness and safety of COVID-19 vaccination prior to and during early pregnancy. Further research is required to extend the safety and efficacy profiles of COVID-19 vaccines to pregnant women and their babies.
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