Magnetic separation-enhanced photoluminescence detection of dipicolinic acid and quenching detection of Cu(II) ions
- 주제(키워드) Dipicolinic acid , Iron oxide nanoparticle , Lanthanide complex , Photoluminescence quenching , Photoluminscence assay
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2024
- URI http://www.dcollection.net/handler/ewha/000000213710
- 본문언어 영어
- Published As https://doi.org/10.1016/j.saa.2023.123501
- PubMed 37839210
초록/요약
Dipicolinic acid (DPA) is a chelate capable of binding to a variety of lanthanide ions to make them luminescent in the visible range. Based on this property and also assisted by magnetic separation, we report a strategy for the sensitive detection of DPA. Poly(acrylic acid)-coated iron oxide nanoparticles (IONPs) serve as a magnetic carrier to deliver only a necessary amount of Tb3+ ions to DPA in a sample solution. This enables photoluminescence measurement of the Tb3+-DPA complex with minimal background noise. The obtained detection limit, which is as low as 0.236 nM, is more than two orders of magnitude lower than that of the assay not assisted by magnetic separation. Not only does this method possess a potential for diagnosing anthrax, given that DPA is a major constituent of Bacillus anthracis spores, but it is also useful for detecting aqueous Cu2+ ions through the luminescence quenching effect. High sensitivity with a detection limit of 54 nM [Cu2+] is demonstrated using the Eu3+-DPA complex. © 2023 Elsevier B.V.
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