Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities
- 주제(키워드) bone cancer , immunotherapy , sarcomas , soft tissue sarcoma , tumor microenviorment
- 주제(기타) Biochemistry & Molecular Biology; Cell Biology
- 설명문(일반) [Jeong, Sehan; Kang, Donghyun; Noh, Jeonghwan; Suh, Jooyeon; Kim, Jin-Hong] Inst for Basic Sci Korea, Ctr RNA Res, Seoul 08826, South Korea; [Jeong, Sehan; Kang, Donghyun; Noh, Jeonghwan; Suh, Jooyeon; Kim, Jin-Hong] Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, Seoul 08826, South Korea; [Afroz, Sharmin; Kim, Yi-Jun] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul 07985, South Korea; [Kim, June Hyuk; Kang, Hyun Guy] Natl Canc Ctr, Res Inst & Hosp, Grad Sch Canc Sci & Policy, Orthopaed Oncol Clin,Ctr Rare Canc, Goyang 10408, South Korea; [You, Hye Jin] Natl Canc Ctr, Res Inst, Div Canc Biol, Canc Microenvironm Branch, Goyang 10408, South Korea; [Kim, Yi-Jun] Ewha Womans Univ, Coll Med, Dept Radiat Oncol, Seoul 07985, South Korea; [Kim, Jin-Hong] Seoul Natl Univ, Bio MAX Inst, BioSeoul 08826, South Korea; [Kim, Jin-Hong] Seoul Natl Univ, Inst Green Bio Sci & Technol, Pyeongchang 25354, South Korea; [Kim, Jin-Hong] Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 08826, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Gold Open Access; Green Published
- 발행기관 KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213864
- 본문언어 영어
- Published As https://doi.org/10.14348/molcells.2023.0079
- PubMed 37853684
초록/요약
Sarcomas are rare and heterogeneous mesenchymal neoplasms originating from the bone or soft tissues, which pose significant treatment challenges. The current standard treatment for sarcomas consists of surgical resection, often combined with chemo-and radiotherapy; however, local recurrence and metastasis remain significant concerns. Although immunotherapy has demonstrated promise in improving long-term survival rates for certain cancers, sarcomas are generally considered to be relatively less immunogenic than other tumors, presenting substantial challenges for effective immunotherapy. In this review, we examine the possible opportunities for sarcoma immunotherapy, noting cancer testis antigens expressed in sarcomas. We then cover the current status of immunotherapies in sarcomas, including progress in cancer vaccines, immune checkpoint inhibitors, and adoptive cellular therapy and their potential in combating these tumors. Furthermore, we discuss the limitations of immunotherapies in sarcomas, including a low tumor mutation burden and immunosuppressive tumor microenvironment, and explore potential strategies to tackle the immunosuppressive barriers in therapeutic interventions, shedding light on the development of effective and personalized treatments for sarcomas. Overall, this review provides a comprehensive overview of the current status and potential of immunotherapies in sarcoma treatment, highlighting the challenges and opportunities for developing effective therapies to improve the outcomes of patients with these rare malignancies.
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