mRNA vaccines: the most recent clinical applications of synthetic mRNA
- 주제(키워드) In vitro transcribed (IVT) mRNA , mRNA vaccines
- 주제(기타) 약학
- 설명문(URI) https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002839099
- 등재 KCI등재
- 발행기관 대한약학회
- 발행년도 2022
- URI http://www.dcollection.net/handler/ewha/000000239795
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-022-01381-7
초록/요약
Synthetic mRNA has been considered as anemerging biotherapeutic agent for the past decades. Recently,the SARS-CoV-2 pandemic has led to the fi rst clinical useof synthetic mRNA. mRNA vaccines showed far surpassinginfl uences on the public as compared to other vaccine platformssuch as viral vector vaccines and recombinant proteinvaccines. It allowed rapid development and production ofvaccines that have never been achieved in history. SyntheticmRNA, called in vitro transcribed (IVT) mRNA, is the keycomponent of mRNA vaccines. It has several advantagesover conventional gene-expressing systems such as plasmidDNA and viral vectors. It can translate proteins in the cytoplasmby structurally resembling natural mRNA and exhibitvarious protein expression patterns depending on how it isengineered. Another advantage is that synthetic mRNA enablesfast, scalable, and cost-eff ective production. Therefore,starting with the mRNA vaccine, synthetic mRNA is nowin the spotlight as a promising new drug development agent. In this review, we will summarize the latest IVT mRNAtechnology such as new mRNA structures or large-scale production. In addition, the nature of the innate immunogenicityof IVT mRNA will be discussed along with its roles inthe development of vaccines. Finally, the principles of the mRNA vaccine and the future direction of synthetic mRNAwill be provided.
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