Pulp and periapical disease as a risk factor for osteonecrosis of the jaw: a national cohort-based study in Korea
- 주제(키워드) Bisphosphonates , Bisphosphonate-associated osteonecrosis of the jaw , Inflammation , Periapical disease , Pulpitis , Root canal therapy
- 주제(기타) Dentistry, Oral Surgery & Medicine
- 설명문(일반) [Baek, Hyeong-Jin; Kim, Keun-Suh; Kwoen, Min-Jeong; Lee, Hyo-Jung] Seoul Natl Univ, Bundang Hosp, Dept Periodontol, Sect Dent, 82 Gumi Ro,173beon Gil, Seongnam 13620, South Korea; [Lee, Hyejin; Lee, Jae-Ryun] Seoul Natl Univ, Bundang Hosp, Dept Family Med, Sect Dent, Seongnam, South Korea; [Park, Jung-Hyun; Kim, Jin-Woo] Ewha Womans Univ, Res Inst Intractable Osteonecrosis Jaw, Coll Med, Dept Oral & Maxillofacial Surg, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Lee, Tae-Yeon] Catholic Univ Korea, Yeouido ST Marys Hosp, Coll Med, Dept Conservat Dent, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published
- 발행기관 KOREAN ACAD PERIODONTOLOGY
- 발행년도 2024
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000240202
- 본문언어 영어
- Published As https://doi.org/10.5051/jpis.2300120006
- PubMed https://pubmed.ncbi.nlm.nih.gov/37524381
초록/요약
Purpose: This longitudinal cohort study aimed to evaluate the relationship between osteonecrosis of the jaw and pulp and periapical disease in patients who were administered bisphosphonates. Methods: Using data from a nationwide cohort, we examined the association among dental caries, pulp and periapical disease, and osteonecrosis of the jaw in women aged >50 years who received bisphosphonates for more than 1 year between 2002 and 2015. Because of ambiguities in the diagnosis of osteonecrosis of the jaw in population-based data, we operationally defined and categorized the condition into established and potential osteonecrosis of the jaw. Results: Pulp and periapical disease significantly increased the development of both established and potential osteonecrosis of the jaw (hazard ratio, 2.21; 95% confidence interval, 1.40-3.48; and hazard ratio, 2.22; 95% confidence interval, 1.65-2.98, respectively). Root canal treatment did not have any influence on the development of osteonecrosis of the jaw. Conclusions: Pulp and periapical disease may be a major risk factor for osteonecrosis of the jaw. The study findings suggest that patients should undergo regular dental examinations to detect pulp and periapical disease before or during the administration of bisphosphonates and that root canal treatment should be considered to decrease the risk of osteonecrosis of the jaw.
more