Identification of New Polyacetylenes from <i>Dendropanax morbifera</i> with PPAR-α Activity Study
- 주제(키워드) <italic>Dendropanax morbifera</italic> Leveille , polyacetylene , AMP-activated protein kinase , cathepsin S , Peroxisome proliferator-activated receptor
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Piao, Donglan; Youn, Isoo; Seo, Eun Kyoung] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Huynh, Thanh-Hau; Oh, Dong-Chan] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; [Kim, Hyun Woo; Noh, Sang Gyun; Chung, Hae Young] Pusan Natl Univ, Coll Pharm, Dept Pharm, Busan 46241, South Korea; [Kim, Hyun Woo; Noh, Sang Gyun; Chung, Hae Young] Pusan Natl Univ, Res Inst Drug Dev, Coll Pharm, Busan 46241, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- OA유형 Gold
- 발행기관 MDPI
- 발행년도 2024
- URI http://www.dcollection.net/handler/ewha/000000245358
- 본문언어 영어
- Published As https://doi.org/10.3390/molecules29245942
- PubMed https://pubmed.ncbi.nlm.nih.gov/39770031
초록/요약
Dendropanax morbifera Leveille is a traditional medicine used to treat migraine headache and dysmenorrhea. In this study, three polyacetylenes, methyl (10E,9R,16R)-16-acetoxy-9-hydroxyoctadeca-10,17-dien-12,14-diynoate (1), methyl (10E,9R,16S)-9,16-dihydroxyoctadeca-10-en-12,14-diynoate (2), and methyl (10Z,9R,16S)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate (3), were isolated from the aerial parts of D. morbifera, together with seven known compounds (4-10). Importantly, the isolates (6 and 8) were found in the family Araliaceae for the first time in this study. Compounds 1-10 were evaluated for their binding affinity to AMPK and CTSS receptors using in silico docking simulations. Only compound 7 increased the protein expression levels of PPAR-alpha, Sirt1, and AMPK when administered to HepG2 cells as a PPAR-alpha agonist. On the other hand, 7 did not produce any significant reduction in CTSS activity. This study could pave the way for the discovery of novel treatments from D. morbifera targeting PPAR-alpha and AMPK.
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