Variable-density velocity-selective magnetization preparation for non-contrast-enhanced peripheral MR angiography
- 주제(키워드) Velocity-selective excitation , RF pulse design , Magnetization preparation , Non-contrast-enhanced magnetic resonance angiography
- 주제(기타) Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
- 설명문(일반) [Kim, Minyoung; Shin, Taehoon] Ewha Womans Univ, Dept Mech & Biomed Engn, Seoul, South Korea; [Kim, Minyoung; Shin, Taehoon] Ewha Womans Univ, Grad Program Smart Factory, Seoul, South Korea; [Hwang, Inpyeong; Choi, Seung Hong] Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea; [Hwang, Inpyeong; Choi, Seung Hong] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul, South Korea; [Park, Jaeseok] Sungkyunkwan Univ, Dept Biomed Engn, Suwon, South Korea; [Park, Jaeseok] Sungkyunkwan Univ, Dept Intelligent Precis Healthcare Convergence, Suwon, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2024
- URI http://www.dcollection.net/handler/ewha/000000245828
- 본문언어 영어
- Published As https://doi.org/10.1007/s13246-024-01464-3
- PubMed https://pubmed.ncbi.nlm.nih.gov/39080207
초록/요약
Velocity-selective (VS) magnetization preparation has shown great promise for non-contrast-enhanced (NCE) magnetic resonance angiography (MRA) with the ability to generate positive angiographic contrast directly using a single 3D acquisition. However, existing VS-MRA methods have an issue of aliased saturation around a certain velocity, known as velocity field-of-view (vFOV), which can cause undesired signal loss in arteries. This study aimed to develop a new version of the VS preparation pulse sequence that overcomes the aliased saturation problem in conventional VS preparation. Utilizing the fact that an excitation profile is the Fourier transform of excitation k-space sampling, we sampled the k-space in a non-uniform fashion by scaling gradient pulses accordingly to have aliased excitation diffused over velocity. The variable density sampling function was numerically optimized to maximize the average of the velocity passband signal while minimizing its variance. The optimized variable density VS magnetization was validated through Bloch simulations and applied to peripheral NCE MRA in healthy subjects. The in-vivo experiments showed that the proposed variable density VS-MRA significantly lowered arterial signal loss observed in conventional VS-MRA, as evidenced by a higher arterial signal-to-noise ratio (58.50 +/- 14.29 vs. 55.54 +/- 12.32; p < 0.05) and improved artery-to-background contrast-to-noise ratio (22.75 +/- 7.57 vs. 20.60 +/- 6.51; p < 0.05).
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