Reinforcing Polycaprolactone (PCL) nanofiber with a recombinant mussel adhesive protein-1 (Rmfp-1)
- 주제(키워드) DOPA , DOPA- Fe3+ complex , PCL , nanofiber , mussel protective coating
- 발행기관 포항공과대학교 일반대학원
- 지도교수 황동수
- 발행년도 2013
- 학위수여년월 2013. 8
- 학위명 석사
- 학과 및 전공 일반대학원 해양학과
- 세부전공 해양바이오신소재
- 원문페이지 52
- 실제URI http://www.dcollection.net/handler/postech/000001627736
- 본문언어 영어
- 저작권 포항공과대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Electrospun Poly (ε-caprolactone) (PCL) nanofibers have been widely used for tissue engineering applications. However, the poor mechanical properties of PCL nanofibers limit their further utilization in hard tissue engineering. To improve the mechanical properties of PCL nanofibers, we fabricated nanofiber mats by blending PCL and recombinant mussel coating protein (Rmfp-1) to mimic the protective coating of mussels (Mytilus species) which is hard (~comparable to epoxy resin) yet flexible(ε~>70%). The stiffness of PCL/Rmfp-1 nanofiber mat increases linearly with the concentration of DOPA-Fe3+ complex which is a key component of the mussel protective coating in mfp-1. Mimicking the mussel protective coating is a new strategy to enhance the mechanical properties of biomedical materials
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